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Methotrexate

Published
Topics: CancersMethotrexateMusculo-skeletal disorders · Safety in BreastfeedingSkin disordersStability in dosette boxes ·
Contents
  1. dm+d
  2. Articles
  3. Medicine Compliance Aid Stability
    1. Maxtrex · Pfizer Ltd
    2. generic · Hospira UK
    3. generic · Orion Pharma (UK) Ltd
    4. generic · Sandoz Ltd
  4. Lactation Safety Information
    1. As antineoplastic
    2. For rheumatoid arthritis
    3. For psoriasis
    4. For inflammatory bowel disease

dm+d

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Articles

Managing interactions with methotrexate

28 December 2023

Using folic acid with methotrexate in rheumatoid arthritis

20 February 2023Folic acid is used to reduce methotrexate associated adverse effects in people with rheumatoid arthritis. This page guides appropriate dosing.

Accessing resources for patients on high risk medicines

19 December 2022A number of resources are available to support the safe use of high-risk medicines. Healthcare professionals should ensure they are available for their patients

Methotrexate: informing intrathecal risk assessment

11 August 2022Methotrexate products vary in their licensed status and other characteristics which affects their suitability for intrathecal administration

Advising on missed or delayed doses of medicines

15 October 2021Guidance to advise people who occasionally forget or are late in taking a dose of their medicine(s).
Search Articles

Medicine Compliance Aid Stability

MaxtrexPfizer Ltd

Pfizer Ltd
Maxtrex
Tablets 2.5mg, 10mg
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Tablets are cytotoxic.
19 August 2022
Usage of Medicines in Compliance Aids

genericHospira UK

Hospira UK
generic
Tablets 10mg
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Tablets are cytotoxic.
20 December 2022
Usage of Medicines in Compliance Aids

genericOrion Pharma (UK) Ltd

Orion Pharma (UK) Ltd
generic
Tablets 2.5mg, 10mg
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Tablets are cytotoxic.
20 December 2022
Usage of Medicines in Compliance Aids

genericSandoz Ltd

Sandoz Ltd
generic
Tablets 2.5mg, 10mg
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Tablets are cytotoxic.
20 December 2022
Usage of Medicines in Compliance Aids

Lactation Safety Information

As antineoplastic

As antineoplastic
Caution
Limited published evidence indicates small amounts in breast milk
If used as monotherapy, monitor infant’s blood count and do not resume breastfeeding until at least 4 days after a dose – longer with high doses
Discontinue breastfeeding if used in combination with other antineoplastics
Safety in Lactation: Antimetabolites
17 September 2018
LactMed

For rheumatoid arthritis

For rheumatoid arthritis
Caution
See summary
Limited published evidence indicates small amounts in breast milk after weekly administration
Monitor infant’s blood count and do not resume breastfeeding until at least 24 hours after a weekly dose not exceeding 25mg
19 September 2019
LactMed

For psoriasis

For psoriasis
Caution
Topical psoriasis preparation / corticosteroid if appropriate
Limited published evidence indicates small amounts in breast milk after weekly administration
Monitor infant’s blood count and do not resume breastfeeding until at least 24 hours after a weekly dose not exceeding 25mg
Safety in Lactation: Systemic preparations for eczema and psoriasis
16 September 2019
Bibliography

For inflammatory bowel disease

For inflammatory bowel disease
Caution
See summary
Limited published evidence indicates small amounts in breast milk after weekly administration
Monitor infant’s blood count and do not resume breastfeeding until at least 24 hours after a weekly dose not exceeding 25mg
Safety in lactation: Drugs for chronic bowel disorders
16 September 2019
Bibliography