Contact Amgen Ltd in all cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.

Accidental exposure to freezing temperatures does not adversely affect the stability of Neupogen.

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

In the event of an inadvertent temperature excursion the following data may be used:
Within its shelf-life and for the purpose of ambulatory use, the patient may remove the product from the refrigerator and store it at room temperature (not above 25°C) for one single period of up to 72 hours. At the end of this period, the product should not be put back in the refrigerator and should be disposed of.

Contact Sandoz Limited in all cases where a deviation from the recommended storage conditions has occurred.
Refer to the electronic medicines compendium (eMC) at www.medicines.org.uk/emc/ for company contact details

In the event of an inadvertent temperature excursion the following data may be used:
Within its shelf-life and for the purpose of ambulatory use, the product may be removed from the refrigerator and stored at room temperature (not above 25°C) for one single period of up to 15 days. At the end of this period, the product should not be put back in the refrigerator and should be disposed of.
Accidental exposure to freezing temperatures for up to 24 hours does not affect the stability of Nivestim. The frozen pre-filled syringes can be thawed and then refrigerated for future use. If exposure has been greater than 24 hours or frozen more than once, then Nivestim should not be used.
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk