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Choosing equivalent doses of oral benzodiazepines

25 January 2022Approximate equivalent doses of oral benzodiazepines to diazepam. Doses are not exact because of differences between the medicines.

Diazepam rectal tubes for managing seizures

5 October 2021A PGD template developed by SPS and supported by NASMeD and JRCALC for ambulance services commissioned by NHS England.

Diazepam solution injection for managing seizures

5 October 2021A national PGD developed by SPS and supported by NASMeD and JRCALC for ambulance services commissioned by NHS England.

What injections can be given orally or via enteral feeding tubes?

6 November 2020This updated Medicines Q&A is a quick reference summary to different types of enteral feeding tubes, in relation to medication issues. Not all enteral feeding…
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Medicine Compliance Aid Stability

genericAccord-UK Ltd

Accord-UK Ltd
generic
Tablets 2mg, 5mg, 10mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Store in airtight containers and protect from light. Max 28 days in MCA.
3 April 2022

Lactation Safety Information

For anxiety

For anxiety
Lorazepam, Oxazepam
Limited published evidence of safety
Long half-life of diazepam and its active metabolites increases risk of accumulation in breastfed infants
Adverse effects reported include sedation and poor feeding
Monitor the infant closely for drowsiness, poor feeding and adequate weight gain
23 September 2020

Rectal / Parenteral For status epilepticus

Rectal / Parenteral
For status epilepticus
Midazolam (buccal) for rectal, Lorazepam/ clonazepam for parenteral
Long half-life increases risk of accumulation in breastfed infants with repeated doses
Adverse effects reported include sedation and poor feeding
Short-term therapy (1-2 doses) considered not to pose a risk to the infant
23 September 2020

For premedication / conscious sedation

For premedication / conscious sedation
Lorazepam
Long half-life increases risk of accumulation in breastfed infants with repeated doses
Adverse effects reported include sedation and poor feeding after prolonged use
Short-term therapy (1-2 doses) considered not to pose a risk to the infant
23 September 2020

For muscle spasm

For muscle spasm
Baclofen
Long half-life increases risk of accumulation in breastfed infants
Adverse effects reported include sedation and poor feeding
23 September 2020