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Botulinum A toxin

Published
Topics: Botulinum A toxinCCG commissioned new medicinesNeurological disorders · New MedicinesNHS England commissioned new medicinesPatent expiriesRenal and urologic disordersSafety in BreastfeedingStability outside the fridge ·
Contents
  1. dm+d
  2. Refrigerated Storage
    1. Botox · Allergan Ltd
    2. Azzalure · Galderma
    3. Dysport · Ipsen
  3. Lactation Safety Information

dm+d

427412002

Refrigerated Storage

BotoxAllergan Ltd

Allergan Ltd
Botox
Powder for solution for injection 50, 100, 200 units/vial

In the event of an inadvertent temperature excursion the following data may be used:

There is no effect on the stability of the product if it is exposed to temperatures:
Within a range of -70°C  to 30°C  for a period of no more than five days (120 hours)

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

The product should be returned to the fridge as soon as possible and marked "use first" if exposed to the storage conditions specified above.
25 March 2021
London MI Service

AzzalureGalderma

Galderma
Azzalure
125 units powder for solution for injection

Contact Galderma in all cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

22 September 2021
London MI Service

DysportIpsen

Ipsen
Dysport
Powder for solution for injection (300units or 500units)

Contact Ipsen in all cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.

12 November 2021
London MI Service

Lactation Safety Information

Yes
-
No published evidence of safety after therapeutic use. Botulism in a mother showed no transfer of toxin to infant via breast milk
No systemic absorption in mother if used correctly. Therefore, not expected to be found in breast milk
Delay cosmetic use until infant weaned
Safety in Lactation: Drugs for movement disorders
8 November 2018
Bibliography