Licensed for intrathecal use
Products licensed for intrathecal use are the first line option and should be used wherever suitable.
There are currently no known trastuzumab products licensed for intrathecal administration.
Not licensed for intrathecal use, limited information available
Products with partial information that are not licensed for intrathecal administration can still sometimes be used. Refer to the advice in our article and complete a risk assessment to enable you to interpret the details below and choose an appropriate product.
Accord (Zercepac®)
Trastuzumab (Zercepac®) powder for concentrate for solution for infusion
Strength
Excipients
L-histidine hydrochloride monohydrate, L-histidine, α, α-trehalose dihydrate, polysorbate 20
Osmolarity
No information
pH
6.0
Endotoxin content
< 12 EU/mL
Amgen (Kanjinti®)
Trastuzumab (Kanjinti®) powder for concentrate for solution for infusion
Strength
Excipients
Histidine, histidine monohydrochloride, trehalose dihydrate, polysorbate 20
Osmolarity
45 – 75 mOsmol/kg
pH
6.0
Endotoxin content
≤ 32 EU/vial
Strength
Excipients
Histidine, histidine monohydrochloride, trehalose dihydrate, polysorbate 20
Osmolarity
45 – 75 mOsmol/kg
pH
6.0
Endotoxin content
≤ 47 EU/vial
Celltrion (Herzuma®)
Trastuzumab (Herzuma®) powder for concentrate for solution for infusion
Strength
Excipients
L-histidine hydrochloride, L-histidine, α,α-trehalose dihydrate, polysorbate 20
Osmolarity
110 – 140 mOsmol/kg
pH
6.0
Endotoxin content
No information
Daiichi Sankyo (Enhertu®)
Trastuzumab deruxtecan (Enhertu®) powder for concentrate for solution for infusion
Strength
Excipients
L-histidine, L-histidine hydrochloride monohydrate, sucrose, polysorbate 80
Osmolarity
No information
pH
No information
Endotoxin content
< 0.3 EU/mg
Napp (Herzuma®)
Trastuzumab (Herzuma®) powder for concentrate for solution for infusion
Strength
Excipients
L-histidine hydrochloride, L-histidine, α,α-trehalose dihydrate, polysorbate 20
Osmolarity
110 – 140 mOsmol/kg
pH
6.0
Endotoxin content
< 1.0 EU/mL
Organon (Ontruzant®)
Trastuzumab (Ontruzant®) powder for concentrate for solution for infusion
Strength
Excipients
L-histidine hydrochloride monohydrate, L-histidine, α,α-trehalose dihydrate, polysorbate 20
Osmolarity
No information
pH
6.0
Endotoxin content
< 6.5 EU/mL
Pfizer (Trazimera®)
Trastuzumab (Trazimera®) powder for concentrate for solution for infusion
Strength
Excipients
L-histidine hydrochloride monohydrate, L-histidine, sucrose, polysorbate 20 (E432)
Osmolarity
No information
pH
6.0
Endotoxin content
≤ 0.32 EU/mg
Roche (Herceptin®) powder for concentrate
Trastuzumab (Herceptin®) powder for concentrate for solution for infusion
Strength
Excipients
L-histidine hydrochloride monohydrate, L-histidine, α,α-trehalose dihydrate, polysorbate 20
Osmolarity
45 – 75 mOsmol/kg
pH
6.0 (in water for injection)
Endotoxin content
≤ 12 EU/vial
Roche (Herceptin®) solution for injection
Trastuzumab (Herceptin®) solution for injection
Strength
Excipients
Recombinant human hyaluronidase (rHuPH20), L-histidine, L-histidine hydrochloride monohydrate, α,α-trehalose dihydrate, L-methionine, polysorbate 20, water for injection
Osmolarity
45 – 75 mOsmol/kg
pH
6.0 (in water for injection)
Endotoxin content
≤ 10 EU/vial
Roche (Kadcyla®)
Trastuzumab emtansine (Kadcyla®) powder for concentrate for solution for infusion
Strength
Excipients
Succinic acid, sodium hydroxide, sucrose, polysorbate 20
Osmolarity
No information
pH
No information
Endotoxin content
< 4 EU/mL