Licensed for intrathecal use
Products licensed for intrathecal use are the first line option and should be used wherever suitable.
There are currently no known vancomycin products licensed for intrathecal administration.
Not licensed for intrathecal use, limited information available
Products with partial information that are not licensed for intrathecal administration can still sometimes be used. Refer to the advice in our article and complete a risk assessment to enable you to interpret the details below and choose an appropriate product.
Bowmed
Strength
Excipients
Sodium hydroxide and hydrochloric acid (for pH adjustment)
Osmolarity
275 – 276 mOsmol/kg
pH
2.5 – 4.5
Endotoxin content
≤ 0.25 EU/mg
Flynn Pharma (Vancocin®)
Strength
Excipients
No information
Osmolarity
No information
pH
2.5 – 4.5
Endotoxin content
≤ 0.25 EU/mg
Generics/Mylan
Strength
Excipients
Sodium hydroxide (for pH adjustment), hydrochloric acid (for pH adjustment)
Osmolarity
No information
pH
2.5 – 4.5
Endotoxin content
No information
Strength
Excipients
Sodium hydroxide (for pH adjustment), hydrochloric acid (for pH adjustment)
Osmolarity
No information
pH
2.5 – 4.5
Endotoxin content
≤ 0.25 EU/mg
Hikma Farmaceutica
Strength
Excipients
None
Osmolarity
No information
pH
2.5 – 4.5
Endotoxin content
≤ 0.25 EU/mg
Laboratorios Azevedos
Strength
Excipients
Sodium hydroxide and hydrochloric acid (for pH adjustment)
Osmolarity
No information
pH
2.5 – 4.5
Endotoxin content
No Information
Strength
Excipients
Sodium hydroxide and hydrochloric acid (for pH adjustment)
Osmolarity
No information
pH
2.5 – 4.5
Endotoxin content
≤ 0.25 EU/mg
MIP Pharma
Strength
Excipients
None
Osmolarity
249 – 291 mOsmol/kg (5mg in 1mL concentration in glucose 5% or sodium chloride 0.9%)
pH
2.5 – 4.5
Endotoxin content
No information
Noriderm
Strength
Excipients
Hydrochloric acid (for pH adjustment)
Osmolarity
No information
pH
2.5 – 4.5
Endotoxin content
No information
Reig Jofre
Strength
Excipients
None
Osmolarity
No information
pH
2.5 – 4.5
Endotoxin content
0.33 EU/mg
Wockhardt
Strength
Excipients
None
Osmolarity
No information
pH
2.5 – 4.5
Endotoxin content
No information
Unlicensed ‘Special’, specified for intrathecal use
Unlicensed medicines that are manufactured in MHRA-licensed Specials Manufacturing Units, at the request of an authorised healthcare professional specifically for intrathecal use.
Barts and The London NHS Trust – specials manufacturing unit
Vancomycin Intrathecal Injection
Strength
20mg in 4mL PFS
Newcastle Specials Pharmacy Production Unit – Royal Victoria Infirmary
Vancomycin Intrathecal Injection
Strength
20mg in 4mL PFS
Royal Liverpool Hospitals Foundation Trust
Vancomycin Intrathecal Injection
Strength
20mg in 4mL PFS