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Using antihistamines during breastfeeding

27 January 2022Guidance on continuing or initiating commonly used antihistamines whilst breastfeeding. Recommendations apply to full term and healthy infants only.
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Medicine Compliance Aid Stability

PhenerganSanofi

Sanofi
Phenergan
Tablets f/c 10mg, 25mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from light. Store in airtight containers.
22 November 2022

Lactation Safety Information

As antihistamine

As antihistamine
Cetirizine/Loratadine. If a sedating antihistamine required chlorphenamine is preferred (see summary)
Sedating antihistamine
No published evidence of safety
Extensive experience of safe use in breastfeeding
May interfere with lactation
Monitor infant for drowsiness
22 May 2017

As a hypnotic

As a hypnotic
Zaleplon, Zopiclone, Zolpidem
No published evidence of safety
Extensive experience of safe use in breastfeeding
May interfere with lactation
Monitor the infant closely for drowsiness, poor feeding and adequate weight gain
3 January 2018

As anti-emetic

As anti-emetic
Prochlorperazine
Antihistamine anti-emetic
No published evidence of safety
Extensive experience of safe use of promethazine in breastfeeding
Occasional, short-term use considered compatible with breastfeeding. Repeated use may pose a risk of infant sedation and may interfere with lactation
4 March 2019