The first stop for professional medicines advice

Adalimumab

Published
Topics: AdalimumabCCG commissioned new medicinesEyes and vision · Gastrointestinal disordersMusculo-skeletal disordersNew MedicinesNHS England commissioned new medicinesPatent expiriesPre-registration new medicines (UK/EU)Safety in BreastfeedingSkin disordersStability outside the fridge ·
Contents
  1. dm+d
  2. Articles
  3. Refrigerated Storage
    1. Humira · AbbVie
    2. Amgevita · Amgen Ltd
    3. Imraldi · Biogen
    4. Hyrimoz · Sandoz
  4. Lactation Safety Information
    1. For rheumatoid arthritis

dm+d

398728003

Articles

Choosing between available adalimumab products

22 February 2023Understand the adalimumab products that are available on contract to the NHS. Choose between them appropriately for organisations or individuals.
Search Articles

Refrigerated Storage

HumiraAbbVie

AbbVie
Humira
40 mg solution for injection pre-filled syringe, pre-filled pen

In the event of an inadvertent temperature excursion the following data may be used:

A single Humira pre-filled syringe or pre-filled pen may be stored at temperatures up to a maximum of 25°C for a period of up to 14 days. The syringe or pen must be protected from light, and discarded if not used within the 14 -day period

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

For information outside of this excursion, contact AbbVie Ltd directly. Refer to the current BNF for company contact details.

25 March 2021
London MI Service

Amgevita Amgen Ltd

Amgen Ltd
Amgevita
Solution for injection in pre-filled syringe/pen

In the event of an inadvertent temperature excursion the following data may be used:
The pre-filled syringe or pre-filled pen may be stored at temperatures up to a maximum of 25°C for a period of up to 14 days. The pre-filled syringe or pre-filled pen must be protected from light, and discarded if not used within the 14-day period.
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

15 March 2021
London MI Service

ImraldiBiogen

Biogen
Imraldi
Solution for injection in a pre-filled pen or syringe

Once exposed to temperatures up to 25°C, the syringe or pen must be used within 28 days or discarded, even if it is returned to the refrigerator.

You should record the date when the syringe or pen is first removed from refrigerator, and the date after which it should be discarded.

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

19 March 2021
London MI Service

HyrimozSandoz

Sandoz
Hyrimoz
20mg and 40mg Solution for injection in pre-filled syringe and pen

In the event of an inadvertent temperature excursion the following data may be used:

A single Hyrimoz pre-filled syringe / pre-filled pen may be stored at temperatures up to a maximum of 25°C for a period of up to 21 days. The pre-filled syringe / pre-filled pen must be protected from light, and discarded if not used within the 21-day period.
The manufacturers have stated that they will deal with temperature excursions on a case by case basis to ensure the most up to date information is provided each time.
Refer to the electronic medicines compendium (eMC) at www.medicines.org.uk/emc/ for company contact details.

14 October 2022
London MI Service

Lactation Safety Information

For rheumatoid arthritis

For rheumatoid arthritis
Caution
See summary
Moderate amount of published evidence of safety indicates small amounts in breast milk which are likely to be degraded in the infant’s GI tract
Long half-life increases risk of accumulation in breastfed infants
Although large protein molecules may appear in colostrum, risk to preterm infants and neonates is considered to be small and unproven
15 September 2019
Bibliography