In the event of an inadvertent temperature excursion the following data may be used:
Minimum temperature 
The storage temperature should not be lower than minus 25°C for Tisseel. Baxter Healthcare Ltd has not tested the impact storage temperatures below minus 25°C may have on Tisseel. There is no information on how extreme low temperatures may impact the product or its components, including the packaging.

Maximum temperature 
In case of a short term excursion of the intended storage or transport temperature, in-house stability data shows that there is no impact to the product quality or performance when exposed to a temperature excursion of not more than minus 15°C.

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk
Contact Baxter for additional information on cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.